Hemoglobin SC Disease: Phenotypic Variability and Therapeutic Options
نویسندگان
چکیده
منابع مشابه
Dyspnea with hemoglobin SC disease.
BUMC PROCEEDINGS 2002;15:86–90 CASE PRESENTATION LINDA S. BANG, MD: A 41-year-old African American woman with sickle cell disease presented to the Baylor University Medical Center emergency department with dyspnea and dry cough for 3 weeks and back, leg, and chest pain for 2 to 3 days. The hemoglobin SC disease had been first diagnosed during pregnancy. Pleural tuberculosis with a left-sided ef...
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Retinopathy is one of the clinical signs of hemoglobin SC disease.1 It is often misunderstood and diagnosed late because it is initially asymptomatic due to its preferential localization in the periphery of the retina.2,3 A 25-year-old man from the Ivory Coast was admitted because of an abdominal pain crisis. The patient, who had sickle cell trait, had mild scleral jaundice and pronounced splen...
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Hemoglobin SC disease is a very prevalent hemoglobinopathy; however, very little is known about this condition specifically. There appears to be an increased risk of thromboembolic events in hemoglobin SC disease, but studies evaluating the hemostatic alterations are lacking. We describe the findings of a cross-sectional observational study evaluating coagulation activation markers in adult pat...
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Parkinson’s disease is an idiopathic, relentlessly progressive, neurologic disorder manifested clinically by tremor, bradykinesia, rigidity, and postural instability. After completing the diagnostic procedure and having verified the need to start drug treatment, we follow the criteria for therapy aimed at maximum benefits with minimal side effects in the short and long term. This paper examines...
متن کاملMolecular and cellular pathogenesis of hemoglobin SC disease.
Solution and cell studies were performed to ascertain why individuals with hemoglobin (Hb) SC have disease whereas those with Hb AS do not. The polymerization of deoxygenated mixtures containing sickle cell Hb (Hb S; alpha 2 beta 2(6)Glu leads to Val) and Hb C (alpha 2 beta 2(6)Glu leads to Lys) was investigated by measurements of delay times and solubilities. In mixtures containing more than 4...
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ژورنال
عنوان ژورنال: American Journal of Biomedical Science & Research
سال: 2020
ISSN: 2642-1747
DOI: 10.34297/ajbsr.2020.07.001194